Nick Bosa is expected to miss multiple weeks with a calf injury suffered in practice, sidelining him for the upcoming game against the Cardinals and clouding his immediate availability. The team has not decided on placing him on injured reserve, with confirmation of prognosis still to come. Reports from NFL Network and ESPN anchor the timeline and emphasize that further updates are forthcoming. The development concentrates the 49ers’ defensive plans around the absence and signals that the team must navigate the next stretch without one of its core rush threats.