Bleacher Report
San Francisco faces a setback as star edge rusher Nick Bosa injures his calf and is expected to miss multiple weeks, potentially forcing an IR stint that could keep him out through at least four games. The 49ers, already carrying a league-leading number of players on IR, must navigate the absence while evaluating whether to place him on the reserve list with a bye looming. Coach Kyle Shanahan indicated some positive development for rookie Mykel Williams, who could resume full participation after a rehab setback. With early-season momentum challenged, the team will rely on depth on the edge and a path to recovery over the next several weeks, including a possible Week 7 return window and strategic timing around the bye. The next schedule includes back-to-back home games against the Broncos and a road matchup with the Seahawks, shaping interim plans and roster decisions.