The Arizona Cardinals enter Week 5 with a drastically altered offensive line after key injuries, most notably losing left tackle Paris Johnson Jr. to a season-ending bicep injury and potentially sitting right guard Isaiah Adams. Jayden Williams, a seventh-round pick, is set to replace Johnson at left tackle, while Jon Gaines could start inside if Adams sits, amid a unit that has struggled to maintain consistency. ESPN metrics reflect the upheaval, ranking the line near the bottom in pass- and run-block efficiency, and the group is contending with underwhelming performers across multiple spots. The situation raises questions about protection for the quarterback and openings for a Lions defense that ranks high in sacks, with coach Mike LaFleur emphasizing adaptive game-planning to spread the strain among linemen. Moving forward, Arizona must navigate a depleted line against a stout opponent and seek stabilizing contributions from younger interior options as they assess their trench play and identity.